atr inhibitor 1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10406	Tuvusertib	M1774,ATR inhibitor 1	Apoptosis , ATM/ATR , Others , Chk
	Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 µΜ) with selective and potentially antitumor activity.Tuvusertib selectively inhibits ATR activity and blocks...		Apoptosis , ATM/ATR , Others , Chk
T3338	Ceralasertib	AZD6738	ATM/ATR
	Ceralasertib (AZD6738) is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM.		ATM/ATR
T10468	Elimusertib hydrochloride(1876467-74-1 free base)	BAY-1895344 hydrochloride	ATM/ATR
	Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumor activity.		ATM/ATR
T61636	ATR-IN-19
	ATR-IN-19 (Compound 15 R-configure) is an ATR inhibitor [1].
T61587	ATR-IN-15
	ATR-IN-15 (compound 1) is a highly potent and orally active inhibitor of ATR kinase with an IC50 of 8 nM. Additionally, ATR-IN-15 demonstrates inhibitory activity against several targets, including human colon tumor cell...
T10407	Gartisertib	ATR inhibitor 2	ATM/ATR
	ATR inhibitor 2 is an orally active, ATP-competitive, and selective ATR inhibitor (Ki <150 pM) with antitumor activity. ATR inhibitor 2 potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylati...		ATM/ATR
T79058	ATR-IN-24		ATM/ATR
	ATR-IN-24 (Compound 1) is an ATR inhibitor with demonstrated anticancer activity [1].		ATM/ATR
T62548	ATR-IN-17
	ATR-IN-17 is a potent inhibitor of ATR kinase with good anti-cancer effects in LoVo cells (IC50: 1 nM).
T61432	ATR-IN-16
	ATR-IN-16 (compound 46) is a highly effective ATR kinase inhibitor, exhibiting considerable anticancer activity in LoVo cells, as demonstrated by its IC 50 value of 410 nM [1].
T61808	ATR-IN-14
	ATR-IN-14 (compound 1) is a powerful ATR kinase inhibitor that significantly inhibits ATR signaling pathways following CHKI protein phosphorylation, demonstrating a remarkable inhibition rate of 98.03% at 25 nM. Moreover...
T79121	ATR-IN-29		ATM/ATR
	ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].		ATM/ATR
T79031	ATR-IN-21		ATM/ATR
	ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].		ATM/ATR
T79033	ATR-IN-22		ATM/ATR
	ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1 μM and demonstrates anti-tumor activity in colon cancer [1].		ATM/ATR
T78959	ATR-IN-23		ATM/ATR
	ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces synthetic lethality in HT-29 cells, suggesting its utility ...		ATM/ATR